I'm not really sure how I've been missing out on this podcast for so long, but I've recently started listening to The Skeptic's Guide to the Universe (or just subscribe directly to the RSS feed here). It's a little long, usually weighing in around 80 minutes or so, but it's worth it. It's published once a week, and I've been listening to it while I've been at the gym all week.
SGU is produced by Dr. Steven Novella of NeuroLogica Blog, among others. It's a refreshing "escape to reality" for those who struggle throughout the week listening to people who just don't seem to have a grasp on science and reality. And unfortunately, many of those people have their own news programs. Anyhow, check the SGU podcast out. It's both informative and humorous, and the 80 minutes goes by pretty quick. That's an added bonus if you're listening to it while driving or exercising, because it makes that activity go by fast too!